What is the role of tacrolimus (TAC) in the treatment of frequently relapsing nephrotic syndrome (FRNS)?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

Tacrolimus

TAC is started at a dose of 0.1 mg/kg daily divided every 12 hours and adjusted to keep the trough level at about 5-10 ng/mL. [77] Our practice is to use the lowest possible dose that sustains remission and to aim for a trough level of about 3-5 ng/mL. TAC trough levels correspond better to AUC than CSA trough levels, allowing better determination of dosing and exposure with TAC than with CSA. [76] As with CSA, continuing low-dose steroid therapy is often necessary to maintain remission, although some patients may eventually be able to discontinue steroids.


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