How are infrequent relapses of pediatric nephrotic syndrome treated?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

For infrequent relapses (1 relapse within 6 months of initial response, or 1-3 relapses in any 12-month period), steroids are resumed, although for a shorter duration than treatment during the initial presentation. Prednisone, 2 mg/kg/day (60 mg/m2/day), is given as a single morning dose until the patient has been free of proteinuria for at least 3 days. Following remission of proteinuria, prednisone is reduced to 1.5 mg/kg (40 mg/m2) given as a single dose on alternate days for 4 weeks. Steroids may then be stopped or gradually tapered. [63, 59]


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