How is acute kidney failure treated in pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

Acute kidney failure may rarely result from complications of INS, from the underlying disease, or from drug therapy. In most cases, acute kidney failure is reversible with the remission of nephrotic syndrome, correction of intravascular volume contraction, or (in patients with acute interstitial nephritis) removal of the inciting agent. [40]

Rheault et al looked at the incidence, epidemiology, and hospital outcomes associated with acute kidney injury in children hospitalized with nephrotic syndrome and found that acute kidney injury occurred in 58.6% of 336 children and 50.9% of 615 hospitalizations. Risk factors for acute kidney injury included SRNS, infection, and nephrotoxic medication exposure. [66]


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