How are thromboembolic complications (TECs) treated in pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

Initial treatment of thromboembolic complications includes thrombolysis with anticoagulants (such as heparin) or fibrinolytic agents (ie, tissue plasminogen activator, streptokinase, urokinase). [35] For secondary prevention, warfarin is often prescribed for a period of as long as 6 months. [41]

Empiric prophylactic anticoagulation is not routinely indicated in INS. Some practitioners advocate the use of long-term, low-dose aspirin in patients with chronic nephrotic syndrome (eg, frequently relapsing nephrotic syndrome, steroid-dependent nephrotic syndrome [SDNS], and SRNS). However, adequate controlled trials examining the use of aspirin have not been performed. [35]


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