What is the prevalence of membranous nephropathy (MN) in pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

MN is a rare finding in INS of childhood, comprising only approximately 1% of biopsies, whereas in adult INS, MN can be found in 25-40% of cases. LM typically reveals thickening of the glomerular basement membrane. Silver staining may demonstrate characteristic "spikes," resulting from protrusion of basement membrane around immune deposits. IF shows fine granular IgG and complement staining along the periphery of the glomerular capillary wall. EM reveals subepithelial electron-dense deposits. [62]


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