How are the types of membranoproliferative glomerulonephritis differentiated in pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

MPGN is also known as mesangiocapillary glomerulonephritis. Glomeruli are typically lobulated in appearance on LM and demonstrate mesangial proliferation. Silver staining may reveal characteristic duplication of the glomerular basement membrane ("tram-track" appearance). IF findings reveal characteristic capillary deposition of C3.

Three types of MPGN are recognized and can be distinguished by EM findings according to the location of immune deposits. Type 1 is subendothelial; type 2 has ribbon-like, dense intramembranous deposits; and type 3 is subendothelial and subepithelial. Some controversy surrounds the existence of type 3 MPGN as a distinct entity or a variant of type 1. [61]


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