What is the significance of a histologic finding of diffuse mesangial proliferation (DMP) in pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

Diffuse mesangial proliferation (DMP) refers to increased mesangial matrix and increased mesangial hypercellularity. IF findings are negative and EM reveals the typical foot process effacement of MCNS. Patients with DMP have an increased incidence of steroid resistance, although whether these patients are at increased risk for progression to kidney failure is unclear. [60]


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