What is the role of a Mantoux test in the workup of pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

A Mantoux test (purified protein derivative [PPD] test) should be performed before steroid treatment to rule out TB infection.

Mantoux testing can be performed concurrent to starting steroids, as treatment with steroids for 48 hours prior to reading the PPD test does not mask a positive result and the risk associated with 2 days of steroid therapy is minimal. If test results are positive, steroids should be stopped immediately.

In children with a positive PPD test, previously positive PPD test, or prior treatment for TB, chest radiography should be performed.


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