What is the role of urine studies in the workup of pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

Microscopic hematuria is present in 20% of cases of INS and cannot be used to distinguish between MCNS and other forms of glomerular disease.

Red blood cell casts, if present, are suggestive of acute glomerulonephritis, such as postinfectious nephritis, or a nephritic presentation of chronic glomerulonephritis, such as membranoproliferative glomerulonephritis (MPGN). Granular casts may be present and are non-specific as to etiology.

The presence of macroscopic (gross) hematuria is unusual in MCNS and suggests another cause, such as MPGN, or a complication of INS, such as renal vein thrombosis.


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