What is the morbidity and mortality associated with pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Since the introduction of corticosteroids, the overall mortality of INS has decreased dramatically from over 50% to approximately 2-5%. Despite the improvement in survival, INS is usually a chronic, relapsing disease and most patients experience some degree of morbidity, including the following:

  • Hospitalization, in some instances.

  • Frequent monitoring both by parents and by physicians.

  • Administration of medications associated with significant adverse events.

  • A high rate of recurrence (relapses in >60% of patients).

  • The potential for progression to chronic kidney failure and end-stage kidney failure.

Additionally, INS is associated with an increased risk of multiple complications, including edema, infection, thrombosis, hyperlipidemia, acute kidney failure, and possible increased risk of cardiovascular disease.

The prognosis varies, depending on whether the nephrotic syndrome is steroid responsive or steroid resistant.

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