What is the prevalence of pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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In the United States, the reported annual incidence rate of nephrotic syndrome is 2-7 cases per 100,000 children younger than 16 years. The cumulative prevalence rate is approximately 16 cases per 100,000 individuals. [41] The International Study of Kidney Disease in Children (ISKDC) found that 76.6% of children with INS had MCNS on kidney biopsy findings, with 7% of cases associated with FSGS. [4, 42]

A study from New Zealand found the incidence of nephrotic syndrome to be almost 20 cases per million children under age 15 years. [43] In specific populations, such as those of Finnish or Mennonite origin, congenital nephrotic syndrome may occur in 1 in 10,000 or 1 in 500 births, respectively. [44]

Some studies have suggested a change in the histology of INS over the past few decades, although the overall incidence of INS has remained stable. The frequency of FSGS associated with INS appears to be increasing. A review of the literature suggested a 2-fold increase in the incidence of FSGS in recent decades. [45] However, another study found no evidence of an increasing incidence of FSGS. [46]

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