What causes acute kidney failure (AKF) in pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Acute kidney failure (AKF) is a rare complication of INS, occurring in about 0.8% of cases. [40] Causes include the following [40] :

  • Rapid progression of underlying disease (nephrotic syndrome other than MCNS, secondary nephrotic syndrome)

  • Bilateral renal vein thrombosis

  • Acute interstitial nephritis (AIN) due to drug therapy (eg, antibiotics, nonsteroidal anti-inflammatory agents [NSAIDs], diuretics)

  • Acute tubular necrosis (ATN) due to hypovolemia or sepsis

Use of ACE inhibitors or angiotensin II receptor blockers (ARBs) in conjunction with volume depletion can also precipitate AKF.

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