How is pediatric nephrotic syndrome defined?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Nephrotic syndrome, or nephrosis, is defined by the presence of nephrotic-range proteinuria, edema, hyperlipidemia, and hypoalbuminemia. Nephrotic-range proteinuria in a 24-hour urine collection is defined in adults as 3.5 g of protein or more per 24 hours, whereas in children it is defined as protein excretion of more than 40 mg/m2/hr to account for varying body sizes throughout childhood. In both adults and children, a first-morning urine protein/creatinine ratio of 2-3 mg/mg or more indicates nephrotic-range proteinuria.

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