What is the role of penicillin in the management of acute poststreptococcal glomerulonephritis (APSGN)?

Updated: Dec 05, 2018
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

A course of penicillin can be administered to avoid contamination of contacts with a nephritogenic strain of streptococci; however, in most instances, these contacts do not develop overt acute glomerulonephritis. [38] Such therapy may not influence the course of the disease in the index patient, but it may alter the response that confers type-specific immunity. To date, only one report suggests that patients with APSGN who receive antibiotic treatment have a milder clinical course. [65] Throat cultures of immediate family members might detect patients who are asymptomatic but infected.


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