What are histologic features of acute poststreptococcal glomerulonephritis (APSGN) observed by electron microscopy?

Updated: Dec 05, 2018
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

Electron microscopy of renal tissue from patients with APSGN usually reveals electron-dense deposits (humps) in the subepithelial space, mostly in the mesangial notch near the glomerular basement membrane reflection over mesangium. A positive correlation exists between glomerular hypercellularity and subepithelial hump formation. During the recovery process, these deposits rapidly disappear, although fragments still may be found in the mesangium, with occasional subepithelial humps with electron-lucent areas. In persistent disease, these humps may not disappear so rapidly.


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