Which tests are performed for evidence of streptococcal infection in the workup of acute poststreptococcal glomerulonephritis (APSGN)?

Updated: Dec 05, 2018
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

Look for evidence of streptococcal infection in all patients. Cultures from either the pharynx or skin may be positive; however, high streptococcal antibody titers are more compelling.

Numerous laboratory tests can be used to measure antibodies to various streptococcal antigens (eg, antistreptolysin O [ASO], antihyaluronidase [AH], anti-DNase B) or to combinations of antigens (eg, streptozyme test). Whichever test is used, a rise in the titer of the antibody, measured at an interval of 2-3 weeks, is more meaningful than a single measurement. An ASO titer of 250 U or higher is highly suggestive of recent streptococcal infection.


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