What is the role of SPEP in the pathogenesis of acute poststreptococcal glomerulonephritis (APSGN)?

Updated: Dec 05, 2018
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

SPEP is another group A streptococcal nephrogenic antigen most often isolated in Latin America, the United States, and Europe. It is a cationic protease with plasmin-binding properties. It localizes to glomeruli in patients with APSGN and is secreted as an exotoxin. Corresponding serum anti-SPEP antibodies occur in most patients during convalescence. SPEP titers correlate better with nephritis than either ASOT or anti-DNase B antibodies.


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