Which medications in the drug class Alpha2 Agonists, Central-Acting are used in the treatment of Neonatal Abstinence Syndrome?

Updated: Dec 20, 2017
  • Author: Ashraf H Hamdan, MD, MBBCh, MSc, MRCP, FAAP; Chief Editor: Santina A Zanelli, MD  more...
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Alpha2 Agonists, Central-Acting

Clonidine (Catapres, Catapres-TTS, Duraclon)

Alpha2-receptor agonists cause a decrease in sympathetic outflow (drop in vasomotor tone). These agents can be used as adjunct for infant with NAS (second- or third-line agent), and they are helpful for infants with acquired dependency, particularly if they are on a dexmedetomidine drip.

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