What are the CNS signs and symptoms of neonatal abstinence syndrome (NAS)?

Updated: Dec 20, 2017
  • Author: Ashraf H Hamdan, MD, MBBCh, MSc, MRCP, FAAP; Chief Editor: Santina A Zanelli, MD  more...
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Infants are suspected of having neonatal abstinence syndrome if they exhibit any of the signs listed below.

CNS dysfunction includes the following features:

  • High-pitched cry

  • Restlessness, with sleep duration less than 1-3 hours after feeding

  • Hyperactive reflexes

  • Jitteriness

  • Tremors

  • Hypertonia

  • Myoclonic jerks

  • Generalized convulsions

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