What is the role of HSV PCR testing in the workup of neonatal sepsis?

Updated: Jun 13, 2019
  • Author: Nathan S Gollehon, MD, FAAP; Chief Editor: Muhammad Aslam, MD  more...
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Answer

No consensus has been reached regarding the inclusion of HSV PCR testing of CSF as part of a routine sepsis workup in the neonate. Practice in this area is variable, with some centers reserving HSV PCR for infants with CSF abnormalities or for infants with clinical symptoms but who have negative cultures and do not respond to antibiotics. [54] However, vesicles are not present in as many as one third of cases of CNS HSV and disseminated HSV. Further research in this area is needed to provide clear practice recommendations.


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