What causes late-onset neonatal sepsis?

Updated: Jun 13, 2019
  • Author: Nathan S Gollehon, MD, FAAP; Chief Editor: Muhammad Aslam, MD  more...
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Answer

Organisms that have been implicated in causing late-onset neonatal sepsis include the following:

  • Coagulase-negative staphylococci

  • E coli

  • Klebsiella

  • Enterobacter

  • Candida

  • GBS

  • Serratia

  • Acinetobacter

  • Anaerobes

  • Many additional less-common organisms

Late-onset sepsis is associated with the following risk factors [20] :

  • Prematurity

  • Central venous catheterization (duration >10 days)

  • Urinary catheterization

  • Chronic mechanical ventilation

  • Failure to advance enteral feeding

  • nasal cannula or continuous positive airway pressure (CPAP)

  • Use of H2 -receptor blocker or proton pump inhibitor (PPI)

  • Gastointestinal tract pathology


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