What causes cholestatic liver disease in patients with necrotizing enterocolitis (NEC)?

Updated: Dec 27, 2017
  • Author: Shelley C Springer, JD, MD, MSc, MBA, FAAP; Chief Editor: Muhammad Aslam, MD  more...
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Answer

Cholestatic liver disease is a multifactorial condition caused by prolonged fasting and total parenteral nutrition. It is characterized by hepatomegaly and elevated aminotransferase and direct bilirubin levels. The treatment is initiation of enteral feedings as early as possible to stimulate bile flow.


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