Which medications in the drug class Natural Sufactant are used in the treatment of Pulmonary Interstitial Emphysema?

Updated: Jun 25, 2019
  • Author: Abhay J Bhatt, MD, MBBS; Chief Editor: Muhammad Aslam, MD  more...
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Natural Sufactant

Beractant (Survanta®), Poractant (Curosurf®), Calfactant (Infasurf®)

It is derived from animals. It has been considered the superior subtype, due to its greater efficacy in mimicking the action of human surfactant. The value between the two subtypes has yet to be fully elucidated. Bovine samples are most commonly used followed by porcine extracts. Despite the positive findings when natural surfactant is administered, there are a number of drawbacks, including the lack of cost-effectiveness, inconsistent efficacy, possible anaphylactic shock reaction, and risk of pathogen contamination. It is important to note that the pathogenic risks have not been identified on a clinical level.

Beractant (Survanta®) is animal surfactant derived from minced bovine lung extract, with the added products of DPPC, palmitic acid and tripalmitin.

Poractant (Curosurf®) is derived from minced porcine lungs.

Calfactant (Infasurf®) is another bovine surfactant extracted by broncho-alveolar lavage

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