Which novel therapies have been used in the treatment of pulmonary interstitial emphysema (PIE)?

Updated: Jun 25, 2019
  • Author: Abhay J Bhatt, MD, MBBS; Chief Editor: Muhammad Aslam, MD  more...
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Answer

Case reports and/or case series describe a variety of other approaches for the management of pulmonary interstitial emphysema (PIE), including the following:

  • A 3-day course of dexamethasone (0.5 mg/kg/d) [42] or hydrocortisone (2 mg/kg/day) [10]
  • Chest physiotherapy with intermittent 100% oxygen in localized and persistent compressive PIE [43]
  • Artificial pneumothorax [44, 45]
  • Multiple pleurotomies [46]
  • Heliox with inhaled nitric oxide [47]
  • Percutaneous catheter insertion [4]

Despite the success claimed by the authors of these reports, the efficacy of the treatment modalities they discussed seem questionable. With advancements in respiratory care, these treatment modalities are rarely used.


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