Which clinical history findings are characteristic of pulmonary interstitial emphysema (PIE)?

Updated: Jun 25, 2019
  • Author: Abhay J Bhatt, MD, MBBS; Chief Editor: Muhammad Aslam, MD  more...
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Pulmonary interstitial emphysema (PIE) is a radiographic and pathologic diagnosis. PIE is associated with few clinical signs, but a progressive, sometimes rapid, increase in oxygen (O2) requirements, carbon dioxide (CO2) retention or hypotension are suggestive of this diagnosis.

Alternatively, the infant can present with the signs of one of the complications of PIE, such as pneumothorax. Occasionally, PIE becomes apparent following reexpansion of a collapsed lung after drainage of a pneumothorax.

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