Which infants are at highest risk for pulmonary interstitial emphysema (PIE)?

Updated: Jun 25, 2019
  • Author: Abhay J Bhatt, MD, MBBS; Chief Editor: Muhammad Aslam, MD  more...
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PIE is more common in infants of lower gestational age, and it usually occurs within the first weeks of life. That is, development of PIE within the first 24-48 hours after birth is often associated with extreme prematurity, very low birth weight, perinatal asphyxia, and/or neonatal sepsis—and frequently indicates a grave prognosis.

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