What are the algorithms for the management of fetus hemolytic disease of the newborn (HDN) during pregnancy?

Updated: Dec 28, 2017
  • Author: Sameer Wagle, MBBS, MD; Chief Editor: Muhammad Aslam, MD  more...
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Answer

In the event of pulmonary immaturity and delta-OD 450 in the affected zone of the Queenan curve, oral administration of 30 mg of phenobarbital to the mother 3 times per day, followed by induction in one week, reduces the need for exchange transfusion in the affected neonate. [66] Excellent algorithms for management of the first affected pregnancy and the pregnancy in a mother with previously affected fetus are outlined in a review by Moise (see the images below). [67]

Management of first affected pregnancy. Management of first affected pregnancy.
Management of pregnant women with previously affec Management of pregnant women with previously affected fetus.

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