How is hemolytic disease of the newborn (HDN) diagnosed?

Updated: Dec 28, 2017
  • Author: Sameer Wagle, MBBS, MD; Chief Editor: Muhammad Aslam, MD  more...
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The diagnosis and management of pregnant women with hemolytic disease of the newborn (HDFN) is based on laboratory and radiographic monitoring. [13]

Hemolytic disease of the newborn is characterized by one or more of the following clinical presentations [33] :

  • Rapidly progressive severe hyperbilirubinemia or prolonged hyperbilirubinemia

  • Positive maternal antenatal antibody findings and/or diagnosis of anemia or fetal hydrops

  • Positive neonatal direct Coombs test (direct antiglobulin test)

  • Hemolysis on blood film findings

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