What causes hemolytic disease of the newborn (HDN)?

Updated: Dec 28, 2017
  • Author: Sameer Wagle, MBBS, MD; Chief Editor: Muhammad Aslam, MD  more...
  • Print

In the absence of a positive direct Coombs test result, other causes of pathologic jaundice should be considered, [11]  including intrauterine congenital infections; erythrocyte membrane defects (eg, hereditary spherocytosis, hereditary elliptocytosis, hereditary pyropoikilocytosis); RBC enzyme deficiencies (eg, glucose-6-phosphate dehydrogenase [G6PD] deficiency, pyruvate kinase deficiency, triosephosphate isomerase deficiency); and nonhemolytic causes (eg, enclosed hemorrhages, hypothyroidism, GI obstruction, and metabolic diseases).

Similarly, hydrops can occur from nonimmune hematologic disorders that cause anemia, such as hemoglobinopathies (eg, α-thalassemia major), cardiac failure due to dysrhythmia, congenital heart defects, and infections (eg, syphiliscytomegalovirus [CMV], parvovirus [12] ).

  • Common causes of hemolytic disease of the newborn

    • Rh system antibodies

    • ABO system antibodies

  • Uncommon causes: Kell system antibodies

  • Rare causes

    • Duffy system antibodies

    • MNS and s system antibodies

  • No occurrence in hemolytic disease of the newborn

    • Lewis system antibodies

    • P system antibodies

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!