Which factors suggest hemolytic disease in patients with breast milk jaundice?

Updated: Dec 07, 2017
  • Author: Prashant G Deshpande, MD; Chief Editor: Muhammad Aslam, MD  more...
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Factors that suggest the possibility of hemolytic disease include the following:

  • Family history of hemolytic disease

  • Onset of jaundice before 24 hours of life

  • Rise in serum bilirubin levels over 0.5 mg/dL/h

  • Pallor, hepatosplenomegaly

  • Rapid increase in serum bilirubin level after 24-48 hours (G6PD deficiency)

  • Ethnicity suggestive of G6PD deficiency

  • Failure of phototherapy to lower bilirubin levels

  • History of Rh-negative mother who did not receive RhoGAM in previous pregnancies when indicated

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