How is hemolysis evaluated in patients with breast milk jaundice?

Updated: Dec 07, 2017
  • Author: Prashant G Deshpande, MD; Chief Editor: Muhammad Aslam, MD  more...
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Answer

If hemolysis is suspected, consider the following tests:

  • Blood type of mother and infant to evaluate for ABO, Rh, or other blood group incompatibility

  • Coombs test, as well as an elution test for antibodies against A or B, to evaluate for immune mediated hemolysis

  • Peripheral smear to look for abnormally shaped RBCs (ovalocytes, acanthocytes, spherocytes, schistocytes)

  • Glucose-6-phosphate dehydrogenase (G6PD) screen, especially if the infant's ethnicity is consistent (eg, black persons, Southeast Asians)


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