What is included in medical care for hypoxic-ischemic encephalopathy (HIE)?

Updated: Jul 18, 2018
  • Author: Santina A Zanelli, MD; Chief Editor: Dharmendra J Nimavat, MD, FAAP  more...
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Therapeutic hypothermia is indicated for infants with moderate-to-severe hypoxic-ischemic encephalopathy (HIE). Supportive management is also critical to prevent additional injury from seizure activity, poor perfusion, electrolyte imbalance, and abnormal glycemic control.

Following initial resuscitation and stabilization, treatment of HIE includes hypothermia therapy for moderate to severe encephalopathy as well as supportive measures focusing on adequate oxygenation, ventilation and perfusion, careful fluid management, avoidance of hypoglycemia and hyperglycemia, and treatment of seizures. [4, 5] Intervention strategies aim to avoid any further brain injury in these infants. [66]

In cases of posterior cranial fossa hematoma, surgical drainage may be lifesaving if no additional pathologies are present.

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