What is the focus of the diagnostic workup for hypoxic-ischemic encephalopathy (HIE)?

Updated: Jul 18, 2018
  • Author: Santina A Zanelli, MD; Chief Editor: Dharmendra J Nimavat, MD, FAAP  more...
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Diagnostic investigations of infants with hypoxic-ischemic encephalopathy (HIE) are directed at establishing the severity and involvement of other organs, as well as to initiate an assessment of the prognosis. To that extent, initial laboratory testing should include determination of cardiac, renal and liver dysfunction.

In the era of therapeutic hypothermia, continuous video-electroencephalographic (EEG) monitoring is essential to assess encephalopathy severity and to monitor for seizures. Brain magnetic resonance imaging (MRI) is typically delayed until after rewarming is complete, although earlier MRI may be helpful in circumstances in which redirection of care is being considered.

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