When do the symptoms of hypoxic-ischemic encephalopathy (HIE) first appear?

Updated: Jul 18, 2018
  • Author: Santina A Zanelli, MD; Chief Editor: Dharmendra J Nimavat, MD, FAAP  more...
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No race or sex predilection has been noted.

By definition, HIE is seen in the newborn period. Preterm infants can also suffer from HIE, but the pathology and clinical manifestations are different. Most often, the condition is noted in infants who are term at birth. The symptoms of moderate-to-severe HIE are almost always manifested at birth or within a few hours after birth.

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