What determines the magnitude of neuronal injury in hypoxic-ischemic encephalopathy (HIE)?

Updated: Jul 18, 2018
  • Author: Santina A Zanelli, MD; Chief Editor: Dharmendra J Nimavat, MD, FAAP  more...
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Answer

At the cellular level, neuronal injury in HIE is an evolving process. The magnitude of the final neuronal damage depends on the duration and severity of the initial insult, combined with the effects of reperfusion injury, and apoptosis. At the biochemical level, a large cascade of events follow hypoxic-ischemic injury.


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