What is included in the management of hypoxic-ischemic encephalopathy (HIE)?

Updated: Jul 18, 2018
  • Author: Santina A Zanelli, MD; Chief Editor: Dharmendra J Nimavat, MD, FAAP  more...
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Following initial resuscitation and stabilization, treatment of HIE is largely supportive and should focus on the following [4, 5] :

  • Adequate ventilation

  • Perfusion and blood pressure management - Studies indicate that a mean blood pressure (BP) above 35-40 mm Hg is necessary to avoid decreased cerebral perfusion

  • Careful fluid management

  • Avoidance of hypoglycemia and hyperglycemia

  • Avoidance of hyperthermia - Hyperthermia has been shown to be associated with increased risk of adverse outcomes in neonates with moderate to severe hypoxic-ischemic encephalopathy [6]

  • Treatment of seizures

  • Therapeutic hypothermia (33º-33.5ºC for 72h) followed by slow and controlled rewarming for infants with moderate to severe HIE [7]

See Treatment and Medication for more detail.

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