How is acute neurologic injury recognized in hypoxic-ischemic encephalopathy (HIE)?

Updated: Jul 18, 2018
  • Author: Santina A Zanelli, MD; Chief Editor: Dharmendra J Nimavat, MD, FAAP  more...
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Guidelines from the American Academy of Pediatrics (AAP) and the American College of Obstetrics and Gynecology (ACOG) for HIE indicate that all of the following must be present for the designation of perinatal asphyxia severe enough to result in acute neurologic injury:

  • Profound metabolic or mixed acidemia (pH < 7) in an umbilical artery blood sample, if obtained

  • Persistence of an Apgar score of 0-3 for longer than 5 minutes

  • Neonatal neurologic sequelae (eg, seizures, coma, hypotonia)

  • Multiple organ involvements (eg, kidney, lungs, liver, heart, intestines)

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