Which respiratory support measures are indicated in the treatment of neonatal early-onset sepsis associated with maternal chorioamnionitis?

Updated: May 08, 2018
  • Author: Fayez M Bany-Mohammed, MD; Chief Editor: Ted Rosenkrantz, MD  more...
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The aforementioned elements of supportive care are essential to reducing morbidity and mortality. Pulmonary hypertension can complicate the management of neonatal sepsis, and inhaled nitric oxide may reverse this complication. The use of inhaled nitric oxide is an established, FDA-approved therapy for hypoxic respiratory failure in late preterm and term infants; it has been used successfully in many level 3 and level 4 units including use during transport. When myocardial dysfunction, cardiovascular collapse, and severe pulmonary hypertension are not reversible, extracorporeal membrane oxygenation (ECMO) may be a life-saving intervention. In critically ill, septic neonates that are near term or term, the importance of early referral for ECMO cannot be overstated.

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