Which antibiotics are used in the treatment of chorioamnionitis?

Updated: May 08, 2018
  • Author: Fayez M Bany-Mohammed, MD; Chief Editor: Ted Rosenkrantz, MD  more...
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Antibiotic agents used in the treatment of chorioamnionitis include the following:

  •  Ampicillin and gentamicin

  • Clindamycin or metronidazole when endometritis is suspected (postdelivery)

  • Vancomycin for penicillin-allergic patients

  • Alternatives: Monotherapy with ampicillin-sulbactam, ticarcillin-clavulanate, cefoxitin, cefotetan, or piperacillin-tazobactam

  • Penicillin G: Used exclusively for GBS intrapartum prophylaxis; if intraamniotic infection is suspected, broaden the antibiotic coverage.

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