What are the contraindications to double-cover antibiotics for the treatment of Pseudomonas infections?

Updated: Dec 17, 2018
  • Author: Selina SP Chen, MD, MPH; Chief Editor: Russell W Steele, MD  more...
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Some exceptions to double-coverage antibiotics include the treatment of simple urinary infection (eg, cystitis) or local skin infection or empiric antibiotic coverage in the febrile patient with neutropenia. However, one of the most controversial topics in management involves combination versus monotherapy treatment. Well-designed studies are still needed to settle this controversy. If monotherapy is chosen, certain antibiotics (eg, aminoglycosides, aztreonam) should not be used as empiric monotherapy.

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