What is the role of lab testing in the diagnosis of Pseudomonas infections?

Updated: Dec 17, 2018
  • Author: Selina SP Chen, MD, MPH; Chief Editor: Russell W Steele, MD  more...
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Answer

Pseudomonas aeruginosa and other Pseudomonas organisms are aerobic, nonfermentative, nonenterobacterial gram-negative bacilli. Obtain 2 sets of blood cultures (ie, aerobic and anaerobic bottles) from different sites before starting empiric antibiotics. The following laboratory results are helpful to confirm a pseudomonal infection:

  • CBC counts revealing leukocytosis with a left shift and bandemia, which indicates possible presence of toxic granulations or vacuoles

  • Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, which may be elevated in infection

  • Metabolic profile revealing any electrolyte abnormalities, degree of dehydration, and worsening renal function


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