What are risk factors for Pseudomonas respiratory infection?

Updated: Dec 17, 2018
  • Author: Selina SP Chen, MD, MPH; Chief Editor: Russell W Steele, MD  more...
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Answer

Respiratory infections

  • Lower respiratory tract infections with P aeruginosa occur almost exclusively in persons with compromised respiratory systems, especially patients with CF. Most bacteremic pseudomonal pneumonia occurs in patients with malignancies and immunodeficiencies.

  • Primary nonbacteremic pseudomonal pneumonia occurs in patients who have colonization of Pseudomonas organisms. It can be hospital-associated in the ICU setting and is associated with positive-pressure ventilation and endotracheal tubes.

  • The pneumonia may be primary or may follow aspiration of the organism from the upper respiratory tract, especially in patients on mechanical ventilation. Alternatively, it may occur as a result of bacteremic spread to the lungs.

  • Because Pseudomonas species can multiply in nebulizer fluid, proper cleaning, sterilization, and disinfection of reusable equipment are required.

  • Pseudomonas risk should be considered and appropriate empiric antibiotics should be started in accordance to Core Measure for Pneumonia.


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