What are the CNS manifestations of P aeruginosa?

Updated: Dec 17, 2018
  • Author: Selina SP Chen, MD, MPH; Chief Editor: Russell W Steele, MD  more...
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Answer

CNS infection (eg, brain abscess, meningitis)

  • CNS infections are more common among patients who are immunocompromised or in patients who recently have undergone a neurosurgical procedure.

  • P aeruginosa has been isolated with increasing frequency in older patients with meningitis, but pseudomonal infections rarely cause neonatal meningitis.

  • Clinical symptoms are indistinguishable from other forms of bacterial meningitis. Symptoms can be nonspecific (eg, headache, fever, nausea, vomiting, disorientation, lethargy, stiff neck).

  • Often, CNS involvement is due to a complication from another site (eg, malignant external otitis). Although CNS complications are rare, they are often fatal. These include meningitis, brain abscess, and dural sinus thrombophlebitis.


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