What is the role of hyaluronate (HA) injections in the treatment of lateral epicondylitis (tennis elbow)?

Updated: Oct 30, 2018
  • Author: Bryant James Walrod, MD; Chief Editor: Craig C Young, MD  more...
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A novel approach to the treatment of chronic lateral epicondylitis is HA injections. Petrella et al looked at treating 331 individuals with lateral elbow pain of greater than 3 months with either 1% sodium HA or saline. This was a double-blinded study, and each group received an injection at baseline and then 1 week later. Participants had not had any recent injections. They were instructed on postinjection care of rest, ice, compression, elevation (RICE) and no formal physical therapy was prescribed. Primary outcomes were improvement on VAS at rest and after elbow grip testing. VAS pain at rest and after grip testing was significantly better in the HA group versus the saline group. There was also improvement in secondary outcomes of grip strength, patient global satisfaction, and assessment of normal elbow function in the HA group versus the saline group. These differences persisted at the 90-day and 365-day follow-up appointments. [35]

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