Which medications in the drug class Macrolide Antibiotics are used in the treatment of Pediatric Pneumonia?

Updated: Jun 05, 2020
  • Author: Muhammad Waseem, MS, MBBS, FAAP, FACEP, FAHA; Chief Editor: Russell W Steele, MD  more...
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Answer

Macrolide Antibiotics

Macrolide antibiotics have bacteriostatic activity and exert their antibacterial action by binding to the 50S ribosomal subunit of susceptible organisms, resulting in inhibition of protein synthesis.

Erythromycin-sulfisoxazole (Pediazole)

Erythromycin is a macrolide antibiotic with a large spectrum of activity that binds to the 50S ribosomal subunit of the bacteria, which inhibits protein synthesis. Sulfisoxazole expands erythromycin's coverage to include gram-negative bacteria and inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA). The dose for the combination of the 2 drugs is based on the erythromycin component.

Azithromycin (Zithromax)

Azithromycin is used to treat mild to moderate microbial infections. Bacterial or fungal overgrowth may result with prolonged antibiotic use.

Clarithromycin (Biaxin)

Clarithromycin inhibits bacterial growth, possibly by blocking dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest.

Erythromycin (E.E.S., E-Mycin, Ery-Tab)

Erythromycin inhibits bacterial growth, possibly by blocking dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest. This drug is used for the treatment of staphylococcal and streptococcal infections. In children, age, weight, and severity of infection determine the proper dosage. When bid dosing is desired, half-total daily dose may be taken q12h. For more severe infections, double the dose.


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