Which medications in the drug class Antibiotics, Other are used in the treatment of Pertussis?

Updated: May 02, 2019
  • Author: Joseph J Bocka, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Antibiotics, Other

The Committee on Infectious Diseases (COID) of the American Academy of Pediatrics (Red Book Committee) currently recommends promptly treating all household and other close contacts (eg, children and staff at daycare centers) with erythromycin to limit secondary transmission. [44] This is regardless of the age or immunization status of contacts.

A 14-day course of oral erythromycin is the antimicrobial therapy of choice for patients with pertussis and for close contacts. Typical dosing schedule is 40-50 mg/kg/day (not to exceed 2 g/day) in 4 divided doses. Some experts prefer the estolate preparation in young infants because of more effective absorption, which may lead to decreased dosing and less frequent dosing intervals.

Erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin)

Erythromycin inhibits bacterial growth, possibly by blocking the dissociation of peptidyl transfer ribonucleic acid (tRNA) from ribosomes, causing RNA-dependent protein synthesis to arrest.

Erythromycin estolate is the antibiotic of choice to prevent interpersonal transfer, because of enhanced absorption, particularly in young infants. (Its effectiveness in prophylaxis for exposed and susceptible persons has not been determined.)

Erythromycin is recommended for household and close contacts (50 mg/kg/day PO qid for 14 days). It is effective in reducing the course and symptoms of pertussis if it is started within the first 10-14 days, but its efficacy has not proven beyond this period.

Azithromycin (Zithromax, Zmax)

Azithromycin inhibits bacterial growth, possibly by blocking the dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent protein synthesis to arrest. It has been shown in several small studies to be effective against pertussis.

Clarithromycin (Biaxin)

Clarithromycin inhibits bacterial growth, possibly by blocking the dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent protein synthesis to arrest. It has been shown in small studies to be effective against pertussis.

Trimethoprim-sulfamethoxazole (Bactrim, Bactrim DS, Septra DS)

This agent inhibits bacterial growth by inhibiting the synthesis of dihydrofolic acid. It can be used as an alternative drug, although its efficacy against pertussis has not been unproven.


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