Are erythromycin and clarithromycin used in the treatment of pertussis (whooping cough)?

Updated: May 02, 2019
  • Author: Joseph J Bocka, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Erythromycin and clarithromycin are not recommended in infants younger than 1 month, because their use has been associated with increased risk of infantile hypertrophic pyloric stenosis (IHPS). Azithromycin is the recommended agent for the youngest patients, although it also carries some risk of IHPS. Patients who are aged 2 months or older with hypersensitivity to macrolides may be treated with trimethoprim-sulfamethoxazole.


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