What is the mortality and morbidity associated with Listeria infection (listeriosis)?

Updated: Jan 09, 2018
  • Author: Terence Zach, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Early onset neonatal listeriosis has a 20-40% mortality rate. [30] Late-onset neonatal listeriosis has a 0-20% mortality rate. The mortality rate in older children is less than 10%. Hydrocephalus, mental retardation, and other CNS sequelae have been reported in survivors of Listeria meningitis.

A French nationwide prospective study by Charlier et al that included 818 listeriosis cases reported that the strongest mortality predictors in both bacteremia and neurolisteriosis were ongoing cancer, multi-organ failure, aggravation of any pre-existing organ dysfunction, and monocytopenia. Blood-culture positive patients and those receiving adjunctive dexamethasone had higher neurolisteriosis mortality. [32]


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