Which histologic findings are characteristic of Legionella infection?

Updated: Nov 13, 2018
  • Author: Mobeen H Rathore, MD, CPE, FAAP, FIDSA; Chief Editor: Russell W Steele, MD  more...
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  • An intense intra-alveolar inflammation without clinically significant intrabronchial exudate is the histologic hallmark finding. Alveoli usually contain a large number of polymorphonuclear leukocytes, alveolar macrophages, and necrotic debris.

  • Organisms are detected both intracellularly and extracellularly.

  • Microabscesses may be present in the lung parenchyma.

  • Fibrin formation and a predominance of histiocytes occur in more advanced stages of disease.

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