Which medications in the drug class HIV, ART Combos are used in the treatment of Pediatric HIV Infection?

Updated: Mar 05, 2020
  • Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

HIV, ART Combos

Combination ARTs are helpful to promote compliance with complex medication regimens.

Emtricitabine/tenofovir AF (Descovy)

NRTI combination product. Indicated in combination with other ART agents (eg, NNRTIs, PIs) for the treatment of HIV-1 infection in adults and pediatric patients aged ≥ 12 y (weight ≥ 35 kg). It is also indicated, in combination with other ARTs other than protease inhibitors that require a CYP3A inhibitor, for the treatment of HIV-1 infection in children weighing 25-35 kg. Tenofovir alafenamide (AF) is a more targeted form of tenofovir that has demonstrated high antiviral efficacy at a dose that is 10 times lower than tenofovir DF, as well as an improved renal and bone safety profile.

Additionally, it is indicated for HIV-1 preexposure prophylaxis (PrEP) for at-risk adults and adolescents to reduce the risk of HIV-1 infection from sex, excluding those who have receptive vaginal sex.

Emtricitabine/tenofovir DF (Truvada)

Indicated, in combination with other antiretroviral agents (eg, NNRTIs, PIs), for the treatment of HIV-1 infection in adults and pediatric patients who weigh at least 17 kg and can swallow the tablet whole.

Additionally, it is also indicated in combination with safer sex practices for preexposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 in adults and adolescents at high risk. 

Lamivudine/zidovudine (3tc/zdv, Combivir)

Combination of 2 NRTIs. It is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in children who weigh at least 30 kg, adolescents, and adults.

Lamivudine/zidovudine/abacavir (Trizivir)

Abacavir is a nucleoside reverse transcriptase inhibitor, which interferes with HIV viral RNA dependent DNA polymerase and inhibits viral replication. Lamivudine and zidovudine are thymidine analogs that inhibit viral replication. Indicated in combination with other ARTs for HIV infection in adults and children aged ≥ 12 years who weigh at least 40 kg.

Lamivudine/abacavir (Epzicom)

Abacavir is a nucleoside reverse transcriptase inhibitor, which interferes with HIV viral RNA dependent DNA polymerase and inhibits viral replication. Lamivudine is a thymidine analog that inhibit viral replication. Indicated in combination with other ARTs for HIV infection in adults and children who weigh at least 25 kg.

Abacavir/dolutegravir/lamivudine (Triumeq)

Indicated for human immunodeficiency virus type 1 (HIV-1) infection in combination with other ARTs in adults and children weighing ≥ 40 kg.

Lamivudine/tenofovir DF (Cimduo)

Combination contains 2 NRTIs (lamivudine 300 mg and tenofovir disoproxil fumarate 300 mg) that is indicated in combination with other ARTs for HIV-1 infection in adults and children who weigh at least 35 kg.


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